Thomas H. Julian
Affiliations. University of Manchester & Manchester Royal Eye Hospital
Christabel Pankhurst Building,University of Manchester
Dover St,
Manchester, M13 9PS
I am an Academic Ophthalmologist at Manchester Royal Eye Hospital and the University of Manchester.
My work spans medical image analysis, deep learning, and multi-omics. As a clinician experienced in advanced computational workflows, I am uniquely positioned to identify critical clinical questions and address them with state-of-the-art analytical approaches.
Clinically, my research centres on ophthalmic and neurodegenerative diseases. My current work focuses on three major themes:
(1) Investigating relationships between ophthalmic imaging traits and systemic disease,
(2) Applying multi-omic pipelines to uncover determinants of human disease, and
(3) Conducting causal inference studies.
I am particularly interested in using deep learning to answer biological questions and develop risk-prediction models. I have previously used variational and adversarial autoencoders for these purposes, and I am now expanding this experience by exploring a range of generative AI architectures to address real-world clinical challenges.
news
| Mar 31, 2026 | 📖 We have published a review surrounding the retinal features present in people with stroke in Current Eye Research - check the pre-print abstract out here |
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| Mar 20, 2026 | |
| Dec 10, 2025 | |
| Dec 08, 2025 | We’ve updated our study on the relationship between the eye and systemic health - updated an pre-print link is coming soon! |
| Nov 18, 2025 | We published a new paper on the role of OCT in prediction of cardiovascular disease. |
selected publications
- Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes. EBioMedicine 68: 103397J. EBIOM, 2021
- Pigmentation and retinal pigment epithelium thickness: a study of the phenotypic and genotypic relationships between ocular and extraocular pigmented tissuesPigment Cell & Melanoma Research, 2025
- Ophthalmic imaging as a measure of cardiovascular and neurological health: a multi-omic analysis of deep-learning derived phenotypesmedRxiv, 2025