Thomas H. Julian

Affiliations. University of Manchester & Manchester Royal Eye Hospital

prof_pic.jpg

Christabel Pankhurst Building,University of Manchester

Dover St,

Manchester, M13 9PS

I am an Academic Ophthalmologist at Manchester Royal Eye Hospital and the University of Manchester.

My work spans medical image analysis, deep learning, and multi-omics. As a clinician experienced in advanced computational workflows, I am uniquely positioned to identify critical clinical questions and address them with state-of-the-art analytical approaches.

Clinically, my research centres on ophthalmic and neurodegenerative diseases. My current work focuses on three major themes:

(1) Investigating relationships between ophthalmic imaging traits and systemic disease,

(2) Applying multi-omic pipelines to uncover determinants of human disease, and

(3) Conducting causal inference studies.

I am particularly interested in using deep learning to answer biological questions and develop risk-prediction models. I have previously used variational and adversarial autoencoders for these purposes, and I am now expanding this experience by exploring a range of generative AI architectures to address real-world clinical challenges.

news

Mar 31, 2026 📖 We have published a review surrounding the retinal features present in people with stroke in Current Eye Research - check the pre-print abstract out here
Mar 20, 2026 :brain: Check out our collaborative work with the great team at SITraN - focussed on exploring metabolites with causal roles in MND risk here)
Dec 10, 2025 :man_scientist: Our pre-print focussed on exploring the mechanistic links between the appearance of the eye and systemic health using deep learning :robot: and multi-omics :dna: data is now updated, check it out here
Dec 08, 2025 We’ve updated our study on the relationship between the eye and systemic health - updated an pre-print link is coming soon! :eyes:
Nov 18, 2025 We published a new paper on the role of OCT in prediction of cardiovascular disease.

selected publications

  1. Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes. EBioMedicine 68: 103397
    TH Julian, N Glascow, ADF Barry, and 8 more authors
    J. EBIOM, 2021
  2. Pigmentation and retinal pigment epithelium thickness: a study of the phenotypic and genotypic relationships between ocular and extraocular pigmented tissues
    Thomas H Julian, Tomas Fitzgerald, UK Biobank Eye, and 3 more authors
    Pigment Cell & Melanoma Research, 2025
  3. Ophthalmic imaging as a measure of cardiovascular and neurological health: a multi-omic analysis of deep-learning derived phenotypes
    Thomas H Julian, Haoran Dou, Jinming Duan, and 9 more authors
    medRxiv, 2025